田芳,女,1979年3月出生,山西晋城人。现任中国农科院副研究员、硕士生导师。
2000年获山西大学微生物学专业理学学士学位,2003年获海燕策略研究中心官网作物遗传与育种专业农学硕士学位。2010年获美国内布拉斯加大学生物学专业哲学博士学位,同年入职农科院植保所,在植物与细菌互作课题组从事研究工作。2016年3月至2017年8月于美国威斯康星大学密尔沃基分校生物系访学一年半时间。
田芳长期从事植物病原细菌与植物互作机制的研究,研究对象包括丁香假单胞菌、水稻白叶枯病菌、细菌性软腐病菌等,致力于解析植物病原细菌的致病机理,毒性因子的作用机制,以及在此基础上进行新型抗菌药物的研发。先后主持国家自然科学基金、北京市自然科学基金等项目,参加973项目、国家自然科学基金、公益性行业(农业)科研专项等项目。研究成果发表在Molecular Plant-Microbe Interaction、Molecular Plant Pathology.、Environmental Microbiology、Applied Environmental Microbiology等植物与病原物互作领域的优秀国际期刊上。近5年发表中英文论文20余篇,代表论文如下。
近5年主要发表论文:
1、Li H., Xue D., Tian F.,* Yuan X., Yang F., Chen H., Hutchins W., Yang C.-H., He C.* 2019. Xanthomonas oryzae pv. oryzae response regulator TriP regulates virulence and exopolysaccharide production via interacting with c-di-GMP phosphodiesterase PdeR. Mol. Plant Microbe Interact. 32: 729-739
2、Yuan X., Zeng Q., Khokhani D., Tian F., Severin G.B., Waters C.M., Xu J., Zhou X., Sundin G. W., Ibekwe A.M., Liu F.*, Yang C.-H.* 2019. A feed-forward signaling circuit controls bacterial virulence through linking cyclic di-GMP and two mechanistically distinct sRNAs, ArcZ and RsmB. Environ. Microbiol. doi: 10.1111/1462-2920.14603.
3、Yu C., Chen H., Tian F., Yang F., Yuan X., Yang C.-H., He C.* 2018. A ten gene-containing genomic island determines flagellin glycosylation: implication for its regulatory role in motility and virulence of Xanthomonas oryzae pv. oryzae. Mol. Plant Pathol. 19:579-592.
4、Xue D., Tian F.,* Yang F., Chen H., Yuan X., Yang C.-H., Chen Y., Wang Q., He C.* 2018. Phosphodiesterase EdpX1 promotes Xanthomonas oryzae pv. oryzae virulence, exopolysaccharide production, and biofilm formation. Appl. Environ. Microbiol. 84. pii: e01717-18.
5、Yu C., Chen Y., Cao Y., Chen H.,* Wang J., Bi Y.-M., Tian F., Yang F., Rothstein S. J., Zhou X., He C. 2018. Overexpression of miR169o, an overlapping MicroRNA in response to both nitrogen limitation and bacterial infection, promotes nitrogen use efficiency and susceptibility to bacterial blight in rice. Plant Cell Physiol. 59:1234-1247.
6、Yuan X.,† Tian F.,† He C., Severin G. B., Waters C. M., Zeng Q., Liu F.,* Yang C.-H.* 2018. The diguanylate cyclase GcpA inhibits the production of pectate lyases via the H-NS protein and RsmB regulatory RNA in Dickeya dadantii. Mol Plant Pathol. doi: 10.1111/mpp.12665.
7、Fan S., Tian F.,* Li J., Hutchins W., Chen H., Yang F., Yuan X., Cui Z., Yang C.-H.,* He C. 2017. Identification of phenolic compounds that suppress the virulence of Xanthomonas oryzae on rice via the type III secretion system. Mol. Plant Pathol. 18: 555-568
8、Yu C., Chen H., Tian F., Yang F., He C.* 2017. RpoN2- and FliA-regulated fliTX is indispensable for flagellar motility and virulence in Xanthomonas oryzae pv. oryzae. BMC Microbiol. 17: 171.
9、Shindo T., Kaschani F., Yang F., Kovács J., Tian F., Kourelis J., Hong T.N., Colby T., Shabab M., Chawla R., Kumari S., Ilyas M., Hörger A.C., Alfano J.R., van der Hoorn R.A.* 2016. Screen of Non-annotated Small Secreted Proteins of Pseudomonas syringae Reveals a virulence factor that inhibits tomato immune proteases. PLoS Pathog.12: e1005874.
10、Yu C., Wang N., Wu M., Tian F., Chen H., Yang F., Yuan X., Yang C.-H., He C.* 2016. OxyR-regulated catalase CatB promotes the virulence in rice via detoxifying hydrogen peroxide in Xanthomonas oryzae pv. oryzae. BMC Microbiol. 16: 269.
11、Yuan X., Khokhani D., Wu X., Yang F., Biener G., Koestler B. J., Raicu V., He C., Waters C. M., Sundin G. W., Tian F.,* Yang C-H.* 2015. Cross-talk between a regulatory small RNA, cyclic-di-GMP signaling, and flagellar regulator FlhDC for virulence and bacterial behaviors. Environ. Microbiol. 17: 4745-4763.
12、Li H., Yu C., Chen H., Tian F.,* He C. 2015. PXO_00987, a putative acetyltransferase, is required for flagellin glycosylation, and regulates flagellar motility, exopolysaccharide production, and biofilm formation in Xanthomonas oryzae pv. oryzae. Microb. Pathog. 85: 50-57.
13、Yang F., Tian F., Chen H., Hutchins W., Yang C.-H., He C.* 2015. The Xanthomonas oryzae pv. oryzae PilZ domain proteins function differentially in cyclic di-GMP binding and regulation of virulence and motility. Appl. Environ. Microbiol. 81: 4358-4367.
14、Yu C.,† Chen H.,† Tian F., Bi Y.-M., Rothstein J. S., Leach J. E., He C.* 2015. Identification of differentially-expressed genes of rice in overlapping responses to bacterial infection by Xanthomonas oryzae pv. oryzae and nitrogen deficiency. J. Integr. Agr. 14: 888-899.
15、Tian F., Yu C., Li H., Wu X., Li B., Chen H., Wu M., He C.* 2015. Alternative sigma factor RpoN2 is required for flagellar motility and full virulence of Xanthomonas oryzae pv. oryzae. Microbiol. Res. 170: 177-183.